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Metronomic oral vinorelbine in advanced breast cancer and non-small-cell lung cancer: current status and future development.

Department of Oncology, AO San Gerardo, via Pergolesi 33, 20052 Monza (MB), Italy. Department of Medical Oncology, Versilia Hospital & Istituto Toscano Tumori, 55041 Lido di Camaiore (LU), Italy. Oncology Unit, San Giovanni di Dio Hospital, 80027 Frattamaggiore (NA), Italy. Division of Urogenital & Head & Neck Cancer, European Institute of Oncology, 20141 Milan, Italy. Division of Medical Senology, European Institute of Oncology, 20141 Milan, Italy. Oncology Unit, AO Ospedale Civile di Legnano, Legnano, 20025 Legnano (MI), Italy. Department of Medical Oncology, Azienda per l'Assistenza Sanitaria No. 5 - Friuli Occidentale, Presidio Ospedaliero di Pordenone, 33170 Pordenone, Italy. Oncology Unit, Villa Scassi Hospital, ASL3-Genovese, 16149 Genoa, Italy. Department of Medical Oncology, Istituto Nazionale Tumori Regina Elena, 00144 Rome, Italy. Department of Medical Oncology, Rovigo Hospital, ULSS18, 45100 Rovigo, Italy. Department of Clinical & Experimental Medicine, Division of Pharmacology, University of Pisa, 56126 Pisa, Italy.

Future oncology (London, England). 2016;(3):373-87
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Abstract

Metronomic chemotherapy (mCT), a frequent administration of low-dose chemotherapy, allows prolonged treatment duration and minimizes the toxicity of standard-dose chemotherapy. mCT has multiple actions against cancer cells including inhibition of angiogenesis and modulation of the immune system. A number of studies lend support to the clinical efficacy of mCT in advanced breast cancer and non-small-cell lung cancer. However, further evidence is necessary to describe the optimal use of mCT and to identify suitable patients. Oral vinorelbine has emerged as a promising metronomic treatment in patients with metastatic breast cancer and non-small-cell lung cancer and is the only orally available microtubule-targeting agent. This paper reviews current evidence on metronomic oral vinorelbine, discusses its management and defines a suitable patient profile on the basis of a workshop of Italian experts.

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Publication Type : Review

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